Description
ARA-290 Peptide (Cibinetide) – High-Purity Research Compound for Nerve Repair & Inflammation Studies
ARA-290, also known as Cibinetide or Helix B Surface Peptide (HBSP), is a synthetic 11-amino acid peptide derived from the tissue-protective domain of erythropoietin (EPO). Unlike full EPO, ARA-290 selectively activates the innate repair receptor (IRR) without stimulating erythropoiesis (red blood cell production). Researchers study it extensively for its potential in neuropathy, nerve regeneration, anti-inflammatory effects, and tissue protection.
Product Specifications
- Sequence: Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH (Pyroglutamic acid at N-terminus)
- Molecular Formula: C₅₁H₈₄N₁₆O₂₁
- Molecular Weight: 1,257.3 g/mol
- Purity: ≥99% (HPLC verified with COA)
- Form: Lyophilized white powder
- Vial Size: [Insert your size, e.g., 15mg / 10mg]
- Solubility: Soluble in sterile water or bacteriostatic water
- Storage: Refrigerate at 2–8°C; for long-term, store at -20°C
How ARA-290 Works (Research Overview)
ARA-290 targets the innate repair receptor (a heteromer of EPO receptor and β-common receptor/CD131). This pathway triggers:
- Reduction of pro-inflammatory cytokines
- Promotion of cell survival and tissue repair
- Neuroprotection and nerve fiber regeneration
- Improved microvascular function without hematological side effects
Key Research Areas
Researchers are actively investigating ARA-290 for:
- Small Fiber Neuropathy (SFN) — Clinical studies in sarcoidosis patients showed improved corneal nerve fiber density, reduced neuropathic pain, and better quality of life after 28 days of use.
- Diabetic Neuropathy — Improvements in metabolic control (HbA1c) and neuropathic symptoms.
- Nerve Injury & Regeneration — Reduced inflammation and promoted remyelination in preclinical models.
- Chronic Inflammation & Tissue Protection — Anti-inflammatory effects via NLRP3 inflammasome inhibition.
- Other exploratory areas: Cardiovascular protection, stress-related depression models, and general tissue repair.
Important: All findings come from preclinical and early clinical research. ARA-290 is for laboratory research use only.
Typical Research Use (For Lab Purposes Only)
Common reconstitution: Use sterile or bacteriostatic water. Researchers typically explore subcutaneous or in-vitro applications. Always follow institutional protocols and safety guidelines. Dosage and duration vary by experimental design.
Why Choose Our ARA-290?
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For Research Use Only — Not for human consumption, medical treatment, or diagnostic purposes. This product is sold strictly for laboratory and scientific research. Always consult relevant regulations in your country.
Related Research Peptides: BPC-157, TB-500, GHK-Cu, and others for regenerative studies.
RESEARCH USE ONLY!
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